|
Primary Myelofibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, immunoblotting revealed that Stim2 levels remained constant as compared to N-ECFCs, while Stim1, Orai1, Orai3, TRPC1 and TRPC4 proteins were over-expressed in PMF-ECFCs.
|
24603752 |
2014 |
|
Pulmonary Hypertension
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.
|
15358862 |
2004 |
|
Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Tuberous Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results indicate that overexpression of TRPC4 protein may be involved in the epileptogenesis of FCD II and TSC.
|
28455787 |
2017 |
|
Right Ventricular Hypertrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ca<sup>2+</sup> handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.
|
29634917 |
2018 |
|
Childhood Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Adult Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Focal cortical dysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated Expression of TRPC4 in Cortical Lesions of Focal Cortical Dysplasia II and Tuberous Sclerosis Complex.
|
28455787 |
2017 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BT-549 and Hs578T cells express high levels of TRPC4 and TRPC1/4, respectively, and are exquisitely, 2000- and 430-fold, more sensitive to englerin A than other TNBC cell lines.
|
31230251 |
2019 |
|
Cerebellar medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OGR1 and TRPC4 are prominently expressed in healthy cerebellar tissue throughout postnatal development and in primary cerebellar medulloblastoma tissues.
|
28627017 |
2017 |
|
Visceral Pain
|
0.200 |
Biomarker
|
phenotype |
RGD |
A rat knockout model implicates TRPC4 in visceral pain sensation.
|
24388923 |
2014 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The sesquiterpene (-)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal cells.
|
29209034 |
2017 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein.
|
27875305 |
2017 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
|
30038709 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
The sesquiterpene (-)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal cells.
|
29209034 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein.
|
27875305 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
|
30038709 |
2018 |
|
Alkalosis
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
TRPC4 expression determines sensitivity of the platelet-type capacitative Ca2+ entry channel to intracellular alkalosis.
|
17074721 |
2006 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Further analysis revealed a profound decrease in transient receptor potential canonical ion channel 4 (TRPC4) Ca(2+) channel expression in RCC cells.
|
18021253 |
2007 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study indicates that TRPC4 loss in RCC leads to impaired Ca(2+) intake, misfolding, retrograde transport and diminished secretion of antiangiogenic TSP1, thus enabling angiogenic switch during RCC progression.
|
18021253 |
2007 |
|
Graft-vs-Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, expression analysis identified PLEC, C8orf48, TRPC4, and ZNF14, as differentially regulated genes in senescent hMSCs that were similarly regulated in those hMSCs which failed to produce a therapeutic effect in a GVHD trial.
|
24496748 |
2014 |
|
Hodgkin Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In accordance, cortisol level tended to be higher in fish fed both supplemented diets at LD compared to fish fed CTRL, but was lower in fish fed TRP4 than in those fed TRP2 under HD condition.
|
31118899 |
2019 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In accordance, cortisol level tended to be higher in fish fed both supplemented diets at LD compared to fish fed CTRL, but was lower in fish fed TRP4 than in those fed TRP2 under HD condition.
|
31118899 |
2019 |